Hey,
You can't filter on Organisational Unit I'm afraid. This hasn't changed from Exchange 2003, it's not possible to generate either an LDAP filter or OPath filter for Organisational Unit.
As for setting the policy, executing New-EmailAddressPolicy does half the work. You also need to force an update with Update-EmailAddressPolicy.
See below or Get-Help Update-EmailAddressPolicy for further details:
http://technet.microsoft.com/en-us/library/aa996869(EXCHG.80).aspx
Th
e GUI does that step for you when you update a policy.
Chris