ODBC V5R4 and Os400 V4R3 its not a accepted combination.
The Windows client is supported connecting to OS400 N ± 2 releases.
http://www-03.ibm.com/systems/i/software/access/connections.htmlNote: OS400 V4R3 its a withdrawal release since 31 Jan 2001
http://www-304.ibm.com/systems/support/i/planning/upgrade/suptschedule.html