Hi,
I have a couple of questions and recommendations as well:
1) Are you able to identify the name of this worm? and what was the taken action by your AV?
2) Do you know any suspicious symptoms on the network/computers? please mention them
My recommendations to you:
1) Patch Management (Use MS WSUS to deploy windows patches)
2) USB Lockdown (This will cut down the number of infections)
3) Force All users to install an AV on their laptops
4) You need to deploy some NAC solution that will check connected computers and remediate them if they don't comply with the policy
5) You need to deploy some Web Filtering solution that will block users from accessing malicious websites and download malwares
A Symantec Certified Specialist @ your service