You can't prevent people from using su by editing sudoers!
What you want is (maybe) to disable su to all users but root. This is done by editing the /etc/pam.d/su file and adding (or removing a comment)
auth required pam_wheel.so
Have a look at the file, some additional options are available.
But you still might want to allow only the exact commands with sudo together with the su restriction.
//jonas