If you have pinned it down to being the backend server, which is what I think it is, my standard procedure at the moment is to reset the virtual directories on all backend Exchange 2003 servers where a CAS will be placed in front.
http://support.microsoft.com/default.aspx?kbid=883380Once the reset is complete, the backend servers are not touched and all traffic for OWA etc is pushed through the CAS.
-M