Question : Best Database to use for VB.NET local program

I am familiar with SQL Server and MS Access, but I've really only used it in a hosting environment.  I've heard of MSDE, but haven't really used it.  What I would like to know is, if I'm developing a VB.NET application that needs a local database, and this program is going to be installed on multiple computers (not releated, each with their own unique database), what is the best database solution?  

Any recommendations?  I realize this may be a loaded question, but I appreciate the help. Thanks !

Answer : Best Database to use for VB.NET local program

If you want to use it locally the best solution is using VB.net + SQL Server + ADO.net

for web based application use  ASP.net + SQL Server + ADO.net