I've used AVG (free personal edition) and a combination of malwarebytes and HiJackThis for quite some time and have had great results. I simply don't get hammered with malware or viruses.
AVG:
http://free.avg.com/Malwarebytes:
www.malwarebytes.orgHiJackThis:
http://www.trendsecure.com/portal/en-US/tools/security_tools/hijackthis/downloadYou can get a brief overview of Hijackthis here:
http://www.bleepingcomputer.com/tutorials/tutorial42.htmlI also used a fee based antimalware suite called spywaredoctor.
Now it does it's job but it is system resource intensive. It seems as it's always reaching out to it's parent site searching for updates. Sometimes it's overprotective as well. To the point of when I attempted to use MSCONFIG Spywaredoctor popped up with a notification of malware.
I would suggest that no matter what tools you decide to use you place them not only on your hard drive but on removeable media as well. Some of the malware that's out there now is pretty viscious. To the point of disabling USB ports, etc. making it hard to load software at times. If you have it in two places it just makes your life easier.
David