OK ... so do you have two (or a block of) external IP addresses?
Your outgoing traffic from the mail server, if it passes through the ISA server, will appear to come from the ISA server itself. As DCMBS says, you will need to NAT directly via the router, which means you will not be able to use the ISA server to publish your mail server.
I'm not sure how you have mapped the mail server to .210 using ISA server.
Either change the MX record to .211 or, if you have two external IPs, bypass the ISA server by assigning the default gateway of the mail server to the router and use the router to publish the mail server.