Are you trying to save files to the c:\ root ? If so, that is not allowed nor is saving to any "virtualizable" folder like \Program Files as the file will end up int he Virtual Store - %userprofile%\AppData\Local\VirtualStore . Here is MS kb927387 - http://support.microsoft.com/kb/927387
If N/Applicable, please provide VBA file output location & the manual save location you tried to save to.