you can try removing anti virus from the affect machine and see if that improves its performance. if not the the problem is not the av is the size of the mailbox. you can find the cleanwipe tool to remove sav from the client here http://www.experts-exchange.com/Software/Internet_Email/Anti-Virus/Symantec/Q_23798519.html
Also what version of sav its running in the client. the orginal release 10.0 all the way to 10.1.6 had several memory leaks and performance fixes