Question : Exchange 2007  421.4.2.1 error

From my Exchange 2007 Server I am unable to send out to a particular domain and getting a 421.4.2.1 error.  The odd thing is it's only happening to this one domain and just started occuring this week.

Answer : Exchange 2007  421.4.2.1 error

How long ago did they make the change?
DNS information is cached. As long as you do not have a zone for that domain locally, then the DNS information is pretty much out of your control.
You could try flushing the cache on the server:

ipconfig /flushdns

However if that doesn't work then the cache is further upstream and out of your control.

-M
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