I can access the default web site through IE since it doesn't use a host header it responds by IP.
It turns out the problem was an ISA firewall rule that was causing the problem, something must of changed either through CIECW or some such after I fixed the SMTP virtual server. I should have double checked this VERY early on before I went on the other tangent, Occum's razor and all.
Now im confused as to why Firefox was working but not IE since assuming it was a firewall issue the whole time why one worked and the other didn't.